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Principal Investigator

Professor Junling Guo (郭俊凌)

NSFC Excellent Professor
College of Biomass Science and Engineering
Sichuan University, Chengdu, China

BPI Visiting Professor
Department of Chemical and Biological Engineering (CHBE)

The University of British Columbia, Vancouver, Canada

Education and Experience


Prof. Guo received his Ph.D. in Chemical and Biomolecular Engineering at The University of Melbourne, Australia. He initialed the pioneering research on polyphenol-based engineering of particle and thin-film systems, including metal-phenolic network (MPN) and polyphenol-based modular assembly method.


Advisor: Prof. Frank Caruso (Fellows of the Royal Society, Fellow of Australian Academy of Science, Fellow of Australian Academy of Technology and Engineering, Deputy Director of the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, CSIRO Eureka Prize for Leadership).



Prof. Guo conducted research and lecturing as Wyss Fellow in the Wyss Institute for Biologically Inspired Engineering at Harvard University, United States. High-impact works have been focused on phenolic-mediated nanoengineering of microbial and mammalian cells. 

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Advisors: Prof. Samir Mitragotri (Member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member, Wyss Institute for Biologically Inspired Engineering).  Prof. Neel Joshi (Associate Professor of Chemical and Biological Engineering, Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member)

Research Areas

Junling Guo is a NSFC Excellent Professor at Sichuan University in China, and BPI Visiting Professor at The University of British Columbia in Canada. He is also the Deputy Director of the Special Committee of Western Returned Scholars Association of China (WRSA) in Chengdu. Prof. Guo obtained his PhD in Chemical and Biomolecular Engineering at The University of Melbourne (Prof. Frank Caruso FRS) and conducted his postdoctoral research as Wyss Fellow in Harvard University (Prof. Samir Mitragotri, Prof. Neel Joshi). He is the Editorial Board Member of Chin. Chem. Lett., etc., and Outstanding Referee of Angew. Chem., Chem. Mater., Adv. Funct. Mater., etc. Prof. Guo is the Principle Investigator of National Natural Science Foundation Projects, etc. Prof. Guo initiated a series of pioneering research on polyphenol-based multifunctional materials, encompassing more than 140 peer-reviewed publications, including Science, Nat. Nanotechnol, Sci. Adv., Nat. Commun., Matter, Angew. Chem., Adv. Mater., etc. His works have been reported by more than 30 international media, including F1000 (Exceptional), EurekAlert!, Harvard Gazette, ChemViews Magazine,, IDI-Online, etc. He is also an entrepreneur who is the holder of numerous patents in the fields of biotechnology, environmental science, and healthcare, and co-founder of several companies.

Fundamental Studies

  • Nat. Nanotechnol. 2016, 11, 1105

  • Sci. Adv. 2021, 7, eabh348

  • Angew. Chem. Int. Ed. 2014, 53, 5546

  • Angew. Chem. Int. Ed. 2019, 58, 9866

  • Angew. Chem. Int. Ed. 2023, e20230346

  • Chem. Mater. 2023, 3c02449

Cellular-Based Biohybrids

  • Science 2018, 362, 813

  • Nat. Commun. 2022, 13, 2117

  • Adv. Mater. 2020, 2003492

  • Angew. Chem. Int. Ed. 2024, e202314501

  • Adv. Sci. 2023, 2207488

Nanostructured Particle Systems

  • ACS Nano 2023, 17, 24, 25136

  • Adv. Funct. Mater. 2020, 1910566

  • Adv. Funct. Mater. 2021, 2103456

  • Adv. Sci. 2019, 6, 1801688

  • Adv. Healthcare Mater. 2023, 12, 2201578

  • Adv. Healthcare Mater. 2023, 12, 2201933

  • Adv. Healthcare Mater. 2015, 4, 1796

  • Adv. Healthcare Mater. 2015, 4, 2170

  • Bioact. Mater. 2022, 16, 95

  • Bioact. Mater. 2022, 17, 526

  • Adv. Biosys. 2018, 1800241

  • Theranostics 2022, 12, 2028

  • Theranostics 2022, 12, 625

Interfacial-Mediated Nanoengineering

  • Matter 2023, 6, 260

  • Adv. Mater. 2013, 25, 2040

  • Adv. Mater. 2023, 202301531

  • Energy Environ. Sci. 2019, 12, 607

  • Adv. Funct. Mater. 2023, 2212856

  • Environ. Sci. Technol. 2023, acs.est.3c03827

  • Adv. Mater. Technol. 2020, 2000240

  • Biomaterials 2020, 235, 119784

  • Biomaterials 2021, 276, 121026

  • InfoMat 2023, e20230074

  • J. Control. Release. 2023, 360, 433

  • J. Hazard. Mater. 2022, 428, 128145

  • J. Hazard. Mater. 2022, 431, 128441


Invited Reviews

  • Chem. Soc. Rev. 2022

  • Bio-derived nanoparticles for advanced therapy


  • Appl. Phys. Rev. 2022

  • Self-assembly of 1D micelles

  • Innov. Mater. 2024

  • Plant bark biomass and material perspective

  • ACS Biomater. Sci. Eng. 2019

  • Polyphenol-based biomaterials

  • Trends Food Sci. Technol. 2021

  • Microorganisms in fermented foods

  • Adv. Nanobiomed. Res. 2023

  • Phenolic-nanocoating on probiotics

  • EES. Catal. 2024

  • Biomass-derived single-atom catalysts


Our mission: use bio-building blocks to create materials 

Natural polyphenols, these plant-derived natural products, were traditionally referred to as vegetable tannins, due to their original use in the industrial process of tanning to convert animal hide into leather. The possibility to exploring the unique physicochemical and biological properties of polyphenols can serve as an important source of inspiration in the search for new and improved materials. A library of functional metal-phenolic network (MPN) nanostructured films and capsules were reported which is based on the coordination between a phenolic ligand and a range of metal ions. Furthermore, the polyphenol-based particle functionalization was discovered by Prof. Guo to facilitate an interfacial molecular interaction-induced self-assembly process. This allowed for the generation of a highly versatile and effective methodology to prepare a large variety of superstructures assembled from a wide range of building blocks. This method displayed significant versatilities of sizes, shapes, microstructures, and compositions as building blocks. The generic nature of this method led to a large family of modularly assembled superstructures including core-satellite, hollow, hierarchically organized supraparticles, and inorganic-biological hybrids. In functional aspects, the polyphenol-based materials were tailored for biosynthesis, seawater uranium extraction, advanced drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), catalysis, electromagnetic (EM) applications, etc.

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