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Principal Investigator

Professor Junling Guo (郭俊凌)

NSFC Excellent Professor
College of Biomass Science and Engineering
Sichuan University, Chengdu, China

BPI Visiting Professor
Department of Chemical and Biological Engineering (CHBE)

The University of British Columbia, Vancouver, Canada

Education and Experience


Prof. Guo received his Ph.D. in Chemical and Biomolecular Engineering at The University of Melbourne, Australia. He initialed the pioneering research on polyphenol-based engineering of particle and thin-film systems, including metal-phenolic network (MPN) and polyphenol-based modular assembly method.


Advisor: Prof. Frank Caruso (Fellows of the Royal Society, Fellow of Australian Academy of Science, Fellow of Australian Academy of Technology and Engineering, Deputy Director of the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, CSIRO Eureka Prize for Leadership).



Prof. Guo conducted research and lecturing as Wyss Fellow in the Wyss Institute for Biologically Inspired Engineering at Harvard University, United States. High-impact works have been focused on phenolic-mediated nanoengineering of microbial and mammalian cells. 

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Advisors: Prof. Samir Mitragotri (Member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member, Wyss Institute for Biologically Inspired Engineering).  Prof. Neel Joshi (Associate Professor of Chemical and Biological Engineering, Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member)

Research Areas

Junling Guo is an NSFC (National Natural Science Foundation of China) Excellent Professor at Sichuan University in China and a BPI Visiting Professor at The University of British Columbia (Canada). He is the Editorial Board Member of Chin. Chem. Lett., etc., and Outstanding Referee of Angew. Chem., Chem. Mater., Adv. Funct. Mater., Colloids Surf. B, etc. Prof. Guo initiated a series of pioneering research on polyphenol-based multifunctional materials, encompassing more than 120 peer-reviewed publications (with citation > 5000, H-index of 37), including Science, Nat. Nanotechnol, Nat. Commun., Sci. Adv., Energy Environ. Sci., Angew. Chem., Matter, Adv. Mater., etc. Prof. Guo explored the use of polyphenols on particle self-assembly for the generation of superstructures and inorganic-biological hybrids. Prof. Guo's works have been reported by more than 20 international scientific media, including F1000 (Exceptional), EurekAlert!, Harvard Gazette, ChemViews Magazine,, IDI-Online, etc. He is also an entrepreneur who is the holder of numerous patents in the fields of biotechnology, environmental science, and healthcare, and founder of several companies.

Fundamental Studies:

Science 2018, 362, 813

Sci. Adv. 2021, 7, eabh348

Nat. Nanotechnol. 2016, 11, 1105

Angew. Chem. Int. Ed. 2014, 53, 5546

Angew. Chem. Int. Ed. 2019, 58, 9866

Angew. Chem. Int. Ed. 2023, e20230346


Matter 2023, 6, 260

Nat. Commun. 2022, 13, 2117

Energy Environ. Sci. 2019, 12, 607

Environ. Sci. Technol. 2023, acs.est.3c03827

Adv. Mater. 2020, 2003492

Adv. Mater. 2023, 202301531

Adv. Mater. 2013, 25, 2040
Adv. Funct. Mater. 2020, 1910566
Adv. Fun
ct. Mater. 2021, 2103456
Adv. Funct. Mater. 2023, 2212856

Adv. Sci. 2019, 6, 1801688

Adv. Sci. 2023, 2207488
Adv. Healthcare Mater. 2023, 12, 2201578
Adv. Healthcare Mater. 2023, 12, 220193

Adv. Healthcare Mater. 2015, 4, 1796

Adv. Healthcare Mater. 2015, 4, 2170

Adv. Mater. Technol. 2020, 2000240

Adv. Biosys. 2018, 1800241

InfoMat 2023, e20230074
Biomaterials 2020, 235, 119784
Biomaterials 2021, 276, 121026

Bioact. Mater. 2022, 16, 95

Bioact. Mater. 2022, 17, 526

J. Control. Release. 2023, 360, 433
Theranostics 2022, 12, 2028
Theranostics 2022, 12, 625

J. Hazard. Mater. 2022, 428, 128145

J. Hazard. Mater. 2022, 431, 128441


Invited Reviews:

Chem. Soc. Rev. 2022, 51, 4287

Bio-derived nanoparticles for advanced therapy

Appl. Phys. Rev. 2022, 9, 021301

Self-assembly of 1D micelles

ACS Biomater. Sci. Eng. 2019, 5, 557

Polyphenol-based biomaterials

Trends Food Sci. Technol. 2021, 116, 940

Microorganisms in fermented foods

Adv. Nanobiomed. Res. 2023

Phenolic-nanocoating on probiotics


Our mission: use bio-building blocks to create materials 

Natural polyphenols, these plant-derived natural products, were traditionally referred to as vegetable tannins, due to their original use in the industrial process of tanning to convert animal hide into leather. The possibility to exploring the unique physicochemical and biological properties of polyphenols can serve as an important source of inspiration in the search for new and improved materials. A library of functional metal-phenolic network (MPN) nanostructured films and capsules were reported which is based on the coordination between a phenolic ligand and a range of metal ions. Furthermore, the polyphenol-based particle functionalization was discovered by Prof. Guo to facilitate an interfacial molecular interaction-induced self-assembly process. This allowed for the generation of a highly versatile and effective methodology to prepare a large variety of superstructures assembled from a wide range of building blocks. This method displayed significant versatilities of sizes, shapes, microstructures, and compositions as building blocks. The generic nature of this method led to a large family of modularly assembled superstructures including core-satellite, hollow, hierarchically organized supraparticles, and inorganic-biological hybrids. In functional aspects, the polyphenol-based materials were tailored for biosynthesis, seawater uranium extraction, advanced drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), catalysis, electromagnetic (EM) applications, etc.

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